 |
Boldo Powder Peumus boldus1 Pound (16 oz) Buy Now
|
|
Purchase a one pound package of Raintree's sustainably harvested boldo leaf powder (Peumus boldus) - rich in active and beneficial phytochemicals that occur naturally in this plant. Boldo has many biologically active chemicals. At least 17 alkaloids have been documented thus far, several of which are believed to be boldo's main active constituents. Much of the biological activity of the plant has been attributed to a single alkaloid called boldine.* Raintree's boldo has been organically grown in Chile and has been milled into a fine powder which is suitable to stuff into capsules or to prepare your own teas, tinctures or extracts. To see pictures of boldo, click here.
Traditional Uses:* for gallstones and as a gallbladder stimulant (to stimulate bile); to tone, balance, and strengthen liver function (increases liver bile and detoxifies the liver); for upper digestive tract disorders (ulcers, sluggish digestion, lack of bile, dyspepsia); for bowel disorders (colitis, leaky gut, constipation, spastic colon, irritable bowel syndrome [IBS]); for
intestinal worms and liver flukes
For more information boldo (Peumus boldus), please refer to the Database File for Boldo in the Tropical Plant Database. For general information on Raintree's available bulk plants and sustainable harvesting practices, please refer to Main Page for Bulk Plants.
This bulk one pound package retails for $20.00. Purchase Boldo Powder Now
Print a PDF Boldo Brochure
Ingredients: 100% pure boldo leaf powder (Peumus boldus). No binders, fillers or additives are used. This product is non-irradiated and non-fumigated. It is organically grown in Chile without any pesticides or fertilizers.
Suggested Use: This plant is best prepared as an infusion (tea): Use one teaspoon of powder for each cup of water. Pour boiling water over herb in cup and allow to steep 10 minutes. Strain tea (or allow settled powder to remain in the bottom of cup) and drink warm. It is traditionally taken in 1/2 cup amounts twice daily. For more complete instructions on preparing herbal infusions, see the Methods for Preparing Herbal Remedies Page.
Contraindications:
- Boldo has demonstrated abortive properties and caused fetal birth defects in animal studies and therefore should not be used during pregnancy or while breast-feeding.
- Chemicals in boldo may thin the blood. Those taking blood-thinning medications (such as Warfarin®) should use with caution or under the supervision of a health practitioner to monitor these possible effects.
Drug Interactions: Boldo may enhance the effects of blood-thinning medications such as Warfarin®. One in vivo study suggests that boldo and/or boldine can decrease metabolic activation and/or metabolism of toxins, drugs, and chemicals in the liver. As such, boldo may decrease the effect or reduce the half-life of certain drugs that are metabolized in the liver.
RELATED PRODUCTS:
Boldo can be found as an ingredient in these proprietary Raintree formulas:
Boldo Tech Report -- A Technical Plant Data Report is available for boldo.
Third-Party Published Research*
This Raintree product has not been the subject of any clinical research.
All available third-party research on boldo can be found at PubMed.
A partial listing of the published research on boldo is shown below:
Antioxidant & Cellular Protective Actions:
Fernández, J. et al. "Effect of boldo (Peumus boldus Molina) infusion on lipoperoxidation induced by cisplatin in mice liver." Phytother Res. 2009; 23(7): 1024-7.
Yu, B., et al."The aporphine alkaloid boldine induces adiponectin expression and regulation in 3T3-L1 cells." J. Med. Food. 2009 Oct; 12(5): 1074-83.
Konrath, E., et al. "Antioxidant and pro-oxidant properties of boldine on hippocampal slices exposed to oxygen-glucose deprivation in vitro." Neurotoxicology. 2008 Nov; 29(6): 1136-40.
Hidalgo, M., et al. "Photostability and photoprotection factor of boldine and glaucine." J. Photochem. Photobiol. B. 2005 Jul; 80(1): 65-9.
O'brien, P., et al. “Boldine and its antioxidant or health-promoting properties.” Chem. Biol. Interact. 2006 Jan; 159(1): 1-17.
Milian, L., et al. “Reactive oxygen species (ROS) generation inhibited by aporphine and phenanthrene alkaloids
semi-synthesized from natural boldine.” Chem. Pharm. Bull. 2004; 52(6): 696-9.
Santanam, N., et al. “A novel alkaloid antioxidant, Boldine and synthetic antioxidant, reduced form of RU486,
inhibit the oxidation of LDL in-vitro and atherosclerosis in vivo in LDLR(-/-) mice.” Atherosclerosis. 2004 Apr; 173(2):203-10.
Schmeda-Hirschmann, G., “Free-radical scavengers and antioxidants from Peumus boldus Mol. ("Boldo").
Free Radic. Res. 2003 Apr; 37(4): 447-52.
Youn, Y. C., et al. “Protective effect of boldine on dopamine-induced membrane permeability transition in brain
mitochondria and viability loss in PC12 cells.” Biochem. Pharmacol. 2002 Feb; 63(3): 495-505.
Jimenez, I., et al. “Protective effects of boldine against free radical-induced erythrocyte lysis.” Phytother. Res. 2000; 14(5): 339–43.
Reiniger, I. W., et al. “Boldine action against the stannous chloride effect.” J. Ethnopharmacol. 1999 Dec; 68(1-3): 345-8.
Ubeda, A., et al. “Iron-reducing and free-radical-scavenging properties of apomorphine and some related
benzylisoquinolines.” Free Radic. Biol. Med. 1993 Aug; 15(2): 159-67.
Speisky, H., et al. “Antioxidant properties of the alkaloid boldine in systems undergoing lipid peroxidation and
enzyme inactivation.” Biochem. Pharmacol. 1991 Jun; 41(11): 1575-81.
Liver Protective & Detoxifying Actions:
Kubinova, R., et al. “Chemoprotective activity of boldine: modulation of drug-metabolizing enzymes.”
Pharmazie. 2001; 56(3): 242–43.
Jimenez, I., et al. “Biological disposition of boldine: in vitro and in vivo studies.” Phytother. Res. 2000 Jun; 14(4): 254-60.
Jang, Y. Y., et al. “Protective effect of boldine on oxidative mitochondrial damage in streptozotocin-induced
diabetic rats.” Pharmacol. Res. 2000; 42(4): 361–71.
Bannach, R., et al. “Cytoprotective and antioxidant effects of boldine on tert-butyl hydroperoxide-induced
damage to isolated hepatocytes.” Cell Biol. Toxicol. 1996 Apr; 12(2): 89-100.
Kringstein, P., et al. “Boldine prevents human liver microsomal lipid peroxidation and inactivation of cytochrome
P4502E1.” Free Radic. Biol. Med. 1995; 18(3): 559–63.
Cederbaum, A. I., et al. “Inhibition of rat liver microsomal lipid peroxidation by boldine.” Biochem, Pharmacol.
1992 Nov; 44(9): 1765-72.
Lanhers, M. C., et al. “Hepatoprotective and anti-inflammatory effects of a traditional medicinal plant of Chile,
Peumus boldus.” Planta Med. 1991; 57(2): 110–15.
Anti-cholesterol, Hypoglycemic, & Anti-platelet Actions:
Chi, T., et al. "Antihyperglycemic effect of aporphines and their derivatives in normal and diabetic rats." Planta Med. 2006 Oct; 72(13):1175-80.
Eltze, M., et al. “Affinity profile at alpha(1)- and alpha(2) - adrenoceptor subtypes and in vitro cardiovascular actions of (+) - boldine.” Eur. J. Pharmacol. 2002; 443(1-3): 151-68.
Teng, C. M., et al. “Antiplatelet effects of some aporphine and phenanthrene alkaloids in rabbits and man.” J. Pharm. Pharmacol. 1997; 49(7): 706–11.
Almeida, E. R., et al. “Toxicological evaluation of the hydro-alcohol extract of the dry leaves of Peumus boldus
and boldine in rats.” Phytother. Res. 2000; 14(2): 99–102.
Chen, K. S., et al. “Antiplatelet and vasorelaxing actions of some aporphinoids.” Planta Med. 1996; 62(2): 133–36.
Digestive Stimulant, Diuretic & Bile Stimulant Actions:
Gotteland, M., et al. “Protective effect of boldine in experimental colitis.” Planta Med. 1997; 63(4): 311–15.
Gotteland, M., et al. “Effect of a dry boldo extract on oro-cecal intestinal transit in healthy volunteers.” Rev. Med. Chil. 1995; 123(8): 955–60.
Lévy-Appert-Collin, M. C., et al. “Galenic preparations from Peumus boldus leaves (Monimiacea).” J. Pharm. Belg. 1977; 32: 13.
Hughes, D. W., et al. “Alkaloids of Peumus boldus. Isolation of laurotetanine and laurolitsine.” J. Pharm. Sci. 1968.
Gallbladder Bile Stimulant Actions:
Speisky, H., et al. “Boldo and boldine: an emerging case of natural drug development.” Pharmacol. Res. 1994 Jan-Feb; 29(1): 1-12.
Tavares, D. C., et al. “Evaluation of the genotoxic potential of the alkaloid boldine in mammalian cell systems in vitro and in vivo.” Mutat. Res. 1994; 321(3): 139–45.
Krug, H., et al. “New flavonol glycosides from the leaves of Peumus boldus Molina.” Pharmazie, 1965; Nov.
Analgesic, Anti-inflammatory, Muscle-Relaxant & Anti-Spasmodic Actions:
Zhao, Q., et al. "Antinociceptive and free radical scavenging activities of alkaloids isolated from Lindera angustifolia Chen." J. Ethnopharmacol. 2006 Jul; 106(3):408-13.
Ivorra, M., et al. "8-NH2-boldine, an antagonist of alpha1A and alpha1B adrenoceptors without affinity for the alpha1D subtype: structural requirements for aporphines at alpha1-adrenoceptor subtypes." Planta Med. 2005 Oct; 71(10): 897-903.
Estelles, R., et al. “Effect of boldine, secoboldine, and boldine methine on angiotensin II-induced neurtrophil recruitment in vivo.” J. Leukoc. Biol. 2005 Sep; 78(3): 696-704.
Kang, J. J., et al. “Studies on neuromuscular blockade by boldine in the mouse phrenic nerve diaphragm.” Planta Med. 1999; 65(2): 178–79.
Kang, J. J., et al. “Effects of boldine on mouse diaphragm and sarcoplasmic reticulum vesicles isolated from
skeletal muscle.” Planta Med. 1998; 64(1): 18–21.
Backhouse, N., et al. “Anti-inflammatory and antipyretic effects of boldine.” Agents Actions 1994; 42(3–4): 114–17.
Ivorra, M. D., et al. “Different mechanism of relaxation induced by aporphine alkaloids in rat uterus.” J. Pharm. Pharmacol. 1993; 45(5): 439–43.
Lanhers, M. C., et al. “Hepatoprotective and anti-inflammatory effects of a traditional medicinal plant of Chile,
Peumus boldus.” Planta Med. 1991; 57(2): 110–15.
Anthelmintic (worm expelling) & Antiparasitic Actions:
van Krimpen, M., et al. "Anthelmintic effects of phytogenic feed additives in Ascaris suum inoculated pigs." Vet. Parasitol. 2009 Nov 13.
Morello, A., et al. “Trypanocidal effect of boldine and related alkaloids upon several strains of Trypanosoma
cruzi.” Comp. Biochem. Physiol. Pharmacol. Toxicol. Endocrinol. 1994; 107(3): 367-71.
Johnson, M. A., et al. “Biosynthesis of ascaridole: iodide peroxidase-catalyzed synthesis of a monoterpene
endoperoxide in soluble extracts of Chenopodium ambrosioides fruit.” Arch. Biochem. Biophys. 1984 Nov;
235(1): 254-66
Anticancerous & Antileukemic Actions:
Gerhardt, D., et al. "Boldine: a potential new antiproliferative drug against glioma cell lines." Invest. New Drugs. 2008 Dec 3.
Stevigny, C., et al. “Cytotoxic and antitumor potentialities of aporphinoid alkaloids.” Curr. Med. Chem. Anti-Cancer Agents. 2005 Mar; 5(2): 173-82.
Gonzalez-Cabello, R., et al. “Effects of boldine on cellular immune functions in vitro.” J. Investig. Allergol. Clin.
Immunol. 1994 May-Jun; 4(3): 139-45.
Antifungal Actions:
Bluma, R., et al. "Control of Aspergillus section Flavi growth and aflatoxin accumulation by plant essential oils."
J. Appl. Microbiol. 2008 Jul; 105(1): 203-14.
|
* The statements contained herein have not been evaluated
by the Food and Drug Administration.
This product is
not intended to treat, cure, mitigate or prevent any disease.
Please refer to our Conditions of Use for this web site and product.
Thank you for your support and
for choosing a Raintree product!
Raintree Nutrition, Inc.
3579 Hwy 50 East, Suite 222
Carson City, NV 89701
(800) 780-5902
(775) 841-4142
(775) 841-4022 Fax
Return to Main Product Page
    
© Copyrighted 1996
to present by Raintree Nutrition, Inc., Carson City, NV 89701. All rights reserved.
Please read the Conditions of Use, Copyright Statement and our Privacy Policy for this web page and web site.
Updated 1-19-2010
|