Clinical References on Cordia (Cordia verbenacea)
Sertié JA, et.al., Anti-inflammatory activity and sub-acute toxicity of artemetin. Planta Med, 56: 1, 1990 Feb, 36-40
(Abstract Available)
Saiki M., et.al., Determination of inorganic components in Brazilian medicinal plants by neutron activation analysis. Biol Trace Elem Res, 26-27:1990 Jul-Dec, 743-50
(Abstract Available)
Hayashi K., et.al., Antiviral activity of an extract of Cordia salicifolia on herpes simplex virus type 1. Planta Med, 56: 5, 1990 Oct, 439-43
(Abstract Available)
Sertié JA., et.al., Pharmacological assay of Cordia verbenacea. III: Oral and topical antiinflammatory activity and gastrotoxicity of a crude leaf extract. J Ethnopharmacol, 31: 2, 1991 Feb, 239-47
(Abstract Available)
Ficarra R., et.al., Leaf extracts of some Cordia species: analgesic and anti-inflammatory activities as well as their chromatographic analysis. Farmaco, 50: 4, 1995 Apr, 245-56
(Abstract Available)
Mikolajczak KL., et.al., A cyanogenetic lipid from Cordia verbenacea DC. seed oil.
Lipids, 4: 6, 1969 Nov, 617-9
Sertié JA, et.al., Pharmacological assay of Cordia verbenacea; Part 1. Anti-inflammatory activity and toxicity of the crude extract of the leaves. Planta Med, 54: 1, 1988 Feb, 7-10
Check Medline for new articles.
Anti-inflammatory activity and sub-acute toxicity of artemetin.
Sertié JA; Basile AC; Panizza S; Matida AK; Zelnik R
Planta Med, 56: 1, 1990 Feb, 36-40
Abstract
The 5-hydroxy-3,6,7,3',4'-pentamethoxyflavone (artemetin) from Cordia verbenacea DC
(Boraginaceae) showed marked anti-inflammatory activity using various experimental models in rats. Artemetin significantly inhibited carrageenin-induced paw edema following oral doses from 30.4 to 153.9 mg.kg-1. The doses of 102.6 and 153.9 mg.kg-1 showed an inhibitory effect similar to that of 50.0 mg.kg-1 of calcium phenylbutazone. The ED50 value of artemetin in rats was estimated to be 67.07 mg.kg-1. Repeated administration of artemetin at doses of 67.07 mg.kg-1 for a 6-day period reduced granuloma formation with a response comparable to that of 20.0 mg.kg-1 of calcium phenylbutazone. This same dose of artemetin also reduced the vascular permeability to intracutaneous histamine. Sub-acute toxicological experiments indicated a very low toxicity.
Determination of inorganic components in Brazilian medicinal plants by neutron activation analysis.
Saiki M; Vasconcellos MB; Sertié JA
Instituto de Pesquisas Energéticas e Nucleares, Radiochemistry Division, São Paulo-SP, Brasil.
Biol Trace Elem Res, 26-27:1990 Jul-Dec, 743-50
Abstract
Instrumental neutron activation analysis (INAA) has been applied to multielemental
determinations of medicinal extracts obtained from the plants. Cordia Verbenacea DC,
Folidago Microglossa DC, and Petiveria Alliacea. Concentrations of the elements Al, Br, Ca, Cl, Co, Cs, Fe, K, La, Mg, Mn, Na, Rb, Sb, and Zn have been determined in dried extracts of these herbs by short and long irradiations under a thermal neutron flux of 10(11)-10(13) n/cm2s in the IEA-R1 nuclear reactor. The NBS Tea Leaves (1572) and NIES Pepperbush (1) reference materials were analyzed simultaneously with the plant extracts. The results obtained in these analyses have shown a good accuracy and reproducibility of the method. The relative errors and the relative standard deviations were less than 10% for most of the elements analyzed.
Antiviral activity of an extract of Cordia salicifolia on herpes simplex virus type 1.
Hayashi K; Hayashi T; Morita N; Niwayama S
Department of Virology, Toyama Medical and Pharmaceutical University, Toyama, Japan.
Planta Med, 56: 5, 1990 Oct, 439-43
Abstract
A partially purified extract (COL 1-6) from whole plant of Cordia salicifolia showed an
inhibitory effect on herpes simplex virus type 1 (HSV-1). The activity of COL 1-6 on
different steps of HSV-1 replication in HeLa cells was investigated. Under single-cycle
replication conditions, COL 1-6 exerted a greater than 99.9% inhibition in virus yield when added to the cells 3 h or 1.5 h before infection, and even when added 8 h after infection the extract still caused a greater than 99% inhibition. The extract has been shown to have a direct virucidal activity. And also, analysis of early events following infection showed that COL 1-6 affected viral penetration in HeLa cells but did not interfere with adsorption to the cells.
Pharmacological assay of Cordia verbenacea. III: Oral and topical antiinflammatory activity and gastrotoxicity of a crude leaf extract.
Sertié JA; Basile AC; Panizza S; Oshiro TT; Azzolini CP; Penna SC
Department of Pharmacology, Universidade de Säo Paulo, Brazil.
J Ethnopharmacol, 31: 2, 1991 Feb, 239-47
Abstract
The antiinflammatory effects and gastrotoxicity of a lyophilized 70% ethanol extract of the leaves of Cordia verbenacea were investigated through experimental models in rats and mice. The oral administration of 1.24 mg/kg of the extract significantly inhibited nystatin-induced oedema. Topical application of the extract at a dose of 0.09 mg/ear in mice was clearly more effective than 1.0 mg/ear of naproxen in the reduction of the ear oedema induced by corton oil. At antiinflammatory doses, the extract showed an important protective effect on the gastric mucosa, reducing significantly the number of gastric lesions.
Leaf extracts of some Cordia species: analgesic and anti-inflammatory activities as well as their chromatographic analysis.
Ficarra R; Ficarra P; Tommasini S; Calabrò ML; Ragusa S; Barbera R; Rapisarda A
Dipartimento Farmaco-Chimico, Università di Messina, Italy.
Farmaco, 50: 4, 1995 Apr, 245-56
Abstract
Leaf preparations of several species of Cordia are used in traditional medicine as remedies for osteoarticular diseases. The analgesic, anti-inflammatory and anti-arthritic activities in the rat of different extracts of C. francisci, C. martinicensis, C. myxa, C. serratifolia and C. ulmifolia leaves were studied. The results obtained showed that the petroleum ether and alcoholic extracts especially of C. francisci, C. myxa and C. serratifolia leaves have a significant analgesic, anti-inflammatory and anti-arthritic activity in the rat. The flavonoids and phenolic derivative content of the five species of genus Cordia leaves was investigated by TLC and determined by reversed-phase HPLC with an acetonitrile/water/acetic acid buffer solvent gradient. UV detection was carried out at 255 and 280 nm. Four flavonoid glycosides, robinin, rutin, datiscoside and hesperidin, one flavonoid aglycone, dihydrorobinetin, two phenolic derivatives, chlorogenic and caffeic acid, were evidenced and determined.
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