Clinical References on Mango (Mangifera indica)
Wauters G, et al. Agglutination of pYV+ Yersinia enterocolitica strains by agglutinin from Mangifera indica. J Clin Microbiol, 1995 Mar
(Abstract Available)
Zhu XM, et al. [Antiviral activity of mangiferin against herpes simplex virus type 2 in vitro] Chung Kuo Yao Li Hsueh Pao, 1993 Sep
(Abstract Available)
Shibahara A, et al. cis-9,cis-15-octadecadienoic acid: a novel fatty acid found in higher plants. Biochim Biophys Acta, 1993 Nov 3
(Abstract Available)
Khan MN, et al. New saponins from Mangifera indica. J Nat Prod, 1993 May
(Abstract Available)
Lakshman MR, et al. Carotenoid-protein complexes. Methods Enzymol, 1993
(Abstract Available)
Carlier C, et al. Efficacy of massive oral doses of retinyl palmitate and mango (Mangifera indica L.) consumption to correct an existing vitamin A deficiency in Senegalese children. Br J Nutr, 1992 Sep
(Abstract Available)
Patel VK, et al. Folklore therapeutic indigenous plants in periodontal disorders in India (review, experimental and clinical approach). Int J Clin Pharmacol Ther Toxicol, 1988 Apr
(Abstract Available)
Idstein H, et al. [Volatile acids in tropical fruits: cherimoya (Annona cherimolia, Mill.), guava (psidium guajava, L.), mango (Mangifera indica, L., var. Alphonso), papaya (Carica papaya, L.)] Z Lebensm Unters Forsch, 1985 May
(Abstract Available)
Le Grand A. [Anti-infective phytotherapies of the tree-savannah, Senegal (occidental Africa). III: A review of phytochemical substances and the antimicrobial activity of 43 species] J Ethnopharmacol, 1989 May
Davidson SK, et al. Differentiation of coagulase-positive and coagulase-negative staphylococci by lectins and plant agglutinins. J Clin Microbiol, 1982 Apr
Saleh NA, et al. Polyphenolics of twenty local varieties of Mangifera indica. Planta Med, 1975 Oct
Subbarayan C, et al. Isolation & characterization of a carotenoid-protein complex from Mangifera indica (mango). Indian J Biochem, 1966 Dec
Martins EMF, et al. [Biochemical aspects of resistance mechamism of mango mangifera indica l. to ceratocystis fimbriata ell. & hals] Arq Inst Biol (Sao Paulo), 1974 Oct-Dec
el-Sissi H, et al. The gallotannins of Rhus coriaria and Mangifera indica. Planta Med, 1971 Apr
el-Sissi HI, et al. Phenolic components of Mangifera indica. IV. Planta Med, 1970 Jan
el-Sissi HI, et al. Phenolic components, plant- and amino-acids of Mangifera indica. V. Planta Med, 1970 Mar
el Sissi HI, et al. Phenolic components of Mangifera indica. II. Planta Med, 1965 Aug
Agglutination of pYV+ Yersinia enterocolitica strains by agglutinin from Mangifera indica.
Wauters G; Charlier J; Janssens M
Microbiology Unit, University of Louvain, Brussels, Belgium.
J Clin Microbiol, 33: 3, 1995 Mar, 772-4
Abstract
Agglutination of 271 strains of Yersinia enterocolitica and related species grown at 37 degrees C by a 0.01% dilution of the agglutinin from Mangifera indica was correlated with the presence of the virulence plasmid. The study of YadA mutants suggested that the YadA protein is the target of the plant agglutinin.
[Antiviral activity of mangiferin against herpes simplex virus type 2 in vitro]
Zhu XM; Song JX; Huang ZZ; Wu YM; Yu MJ
Department of Microbiology, Hengyang Medical College, China.
Chung Kuo Yao Li Hsueh Pao, 14: 5, 1993 Sep, 452-4
Abstract
The effect of mangiferin, a tetrahydroxy pyrrolidone saponin extracted from the leaves of mango (Mangifera indica), against herpes simplex virus type 2 (HSV-2) in vitro was studied. The 50% effective concentration (EC50) of it against HSV-2 plaque formation in HeLa cells was 111.7 micrograms.ml-1, and the concentrations of 33 and 80 micrograms.ml-1 reduced the virus replicative yields by 90% (EC90) and 99% (EC99), respectively. The therapeutic index (IC50/EC50) was 8.1. Mangiferin did not directly inactivate HSV-2. The results of the drug addition and removal tests suggest that mangiferin inhibits the late event in HSV-2 replication.
cis-9,cis-15-octadecadienoic acid: a novel fatty acid found in higher plants.
Shibahara A; Yamamoto K; Shinkai K; Nakayama T; Kajimoto G
Department of Nutrition, Kobe-Gakuin University, Japan.
Biochim Biophys Acta, 1170: 3, 1993 Nov 3, 245-52
Abstract
An unusual fatty acid, cis-9,cis-15-octadecadienoic acid, has been identified in the pulp lipids of mango (Mangifera indica L.) grown in the Philippines. To our knowledge, the occurrence of cis-9,cis-15-octadecadienoic acid in higher plant lipids has not been previously reported. The structure confirmation was based on the results of chromatographic (capillary GC, argentation thin-layer) and spectrometric (GC-MS, infrared, ultraviolet) analysis and chemical treatment. This butylene-interrupted dienoic fatty acid is concentrated in the pulp part of mango fruit and occupies 5.4% of total acyl groups in the pulp lipids; whereas a common octadecadienoic acid, linoleic acid, is a minor component (1.1%) in the same lipids. If a trivial name is desired, it is suggested that cis-9,cis-15-octadecadienoic acid be called "mangiferic" acid.
New saponins from Mangifera indica.
Khan MN; Nizami SS; Khan MA; Ahmed Z
Department of Chemistry, University of Karachi, Pakistan.
J Nat Prod, 56: 5, 1993 May, 767-70
Abstract
Two new terpenoidal saponins, indicoside A [1] and indicoside B [2], were isolated from Mangifera indica. Their structures were determined as 28-hydroxylupa-12,20(29)-diene-3-O-[beta-glucopyranosyl-(1-->2)] [-beta-glucopyranosyl-(1-->3)]-alpha-L-arabinopyranoside [1] and 28-hydroxylupa-12,20(29)-diene-3-O-[beta-glucopyranosyl-(1-->3)-al pha-L-rhamnopyranosyl-(1-->2)][beta-glucopyranosyl(1-->3)]-alpha-L- arabinopyranoside [2] on the basis of chemical and spectroscopic studies.
Carotenoid-protein complexes.
Lakshman MR; Okoh C
Department of Medicine, George Washington University, Washington, D.C 20037.
Methods Enzymol, 214:1993, 74-86
Abstract
This chapter provides an updated report of carotenoprotein-related research. Very few carotenoproteins have been purified; however, their presence in aqueous extracts may be indicated by spectroscopic evidence. Carotenoproteins have been isolated, purified, and characterized from the ectoderm, exoskeleton, eggs, and ovaries of marine invertebrates, especially crustaceans. Water-soluble and detergent-soluble carotenoid-protein complexes have also been isolated from the cytoplasmic membrane of some cyanobacteria, Mangifera indica, and carrots. Recently, we have been able to partially purify a beta-carotene-protein complex from fresh livers of rats fed beta-carotene. Studies are currently in progress to purify and characterize the protein. This is the first successful isolation of a vertebrate carotenoprotein. The isolation of carotenoproteins is generally by standard techniques of protein chemistry. Purification, crystallization of the complex, and reconstitution of apoprotein and carotenoid components have been achieved for some crustacean carotenoproteins. The complex is very sensitive to bright light and to temperatures above that of refrigeration. However, it is best preserved in solutions of high ionic strength or as a precipitate in strong ammonium sulfate solutions.
Efficacy of massive oral doses of retinyl palmitate and mango (Mangifera indica L.) consumption to correct an existing vitamin A deficiency in Senegalese children.
Carlier C; Etchepare M; Ceccon JF; Mourey MS; Amédée-Manesme O
Institut National de la Santé et de la Recherche Médicale (INSERM), Unité 56, Hôpital de Bicêtre, France.
Br J Nutr, 68: 2, 1992 Sep, 529-40
Abstract
Administration of large oral doses of retinyl palmitate has become the most widely practised vitamin A deficiency prevention strategy in developing countries. We conducted a follow-up study among 220 Senegalese children aged 2-7 years suffering from moderate undernutrition to determine the efficacy of vitamin A treatment on their vitamin A status assessed by biochemical and cytological (impression cytology with transfer) methods. The first examination (T = 0 m[onth]) was carried out during April 1989, before the mango (Mangifera indica L,) harvest. The second examination (T = 2 m) was carried out 2 months after vitamin A treatment during June 1989 when ripe mangoes become widely available. Conjunctival cells of the eyes of the children with or without ocular inflammation were responsive to vitamin A administration (P < 0.01). There was a significant increase (P < 0.001) in mean serum retinol and beta-carotene levels between T = 0 m and T = 2 m. Mean serum retinol-binding protein (RBP) and transthyretin (TTR) levels did not differ significantly (P > 0.05) at T = 0 m and T = 2 m. Despite the intake of vitamin A, 54% of the children who had abnormal cytology at T = 0 m remained abnormal at T = 2 m. This was due to inadequate levels of TTR and RBP, presumably due to the cereal diet eaten by the Senegalese population. children with abnormal eye cytology had lower serum retinol levels than those with normal eyes at T = 0 m, and beta-carotene values did not correlate with eye cytological abnormalities at T = 0 m. Children with normal cytology had higher serum retinol and also beta-carotene levels than those with abnormal cytology after massive oral doses of vitamin A and consumption of mangoes at T = 2 m. Retinyl palmitate may, therefore, only lead to partial cytological improvement due to a lack of retinol-carrier proteins but dietary beta-carotene may also be involved.
Folklore therapeutic indigenous plants in periodontal disorders in India (review, experimental and clinical approach).
Patel VK; Venkatakrishna-Bhatt H
Department of Pharmacology and Therapeutics, Government Dental College and Hospitals, Asarva, Civil Hospital Compound, Ahmedabad, Gujarat, India.
Int J Clin Pharmacol Ther Toxicol, 26: 4, 1988 Apr, 176-84
Abstract
Though a number of plants and their parts are used for dental ailments among population in rural and urban areas of developing countries, in India however, the most common house-hold, road-side plants are mango (Mangifera indica), neem (Azadirachta indica; Melia azadirachta), ocimum (Ocimum basilicum), tea-dust (Camellia sinensis) and uncommonly murayya, i.e., currey leaf (Murayya koenigi) [Chopra et al. 1958, Kirtikar and Basu 1935, Nadakarni 1954, Satyavati 1984]. The leaves of these plants are folded and brushed (massage with teadust) against the teeth. Therefore, the present study is restricted only to the fleshy leaf extracts [Jindal et al. 1975] (except tea) of these plants inspite of certain limitations in the methodology and arbitrations in the microbial identification and isolation in the light of recent advances in folk dentistry. The investigation was carried out in two parts: 1) Experimental study: The efficacy of various dentifrices (commonly available in the market) and the potentiating effect of the leaf extract (LE) of the aforesaid indigenous plants when amalgamated with the tooth-paste against pathogens, were investigated. Further, the protection afforded by the said plant extracts (PE) over the conventional allopathic medicines on the human plaque cultures and gram negative bacteria from patients were studied. 2) Clinical study: The therapeutic effects of the said PE (individually) on clinical application among severely infected patients were examined.
[Volatile acids in tropical fruits: cherimoya (Annona cherimolia, Mill.), guava (psidium guajava, L.), mango (Mangifera indica, L., var. Alphonso), papaya (Carica papaya, L.)]
Idstein H; Bauer C; Schreier P
Z Lebensm Unters Forsch, 180: 5, 1985 May, 394-7
Abstract
The volatile acids extracted by pentane/dichloromethane (2 + 1) from tropical fruit pulps were identified and determined by capillary gas chromatography (HRGC) and combined capillary gas chromatography-mass spectrometry using EI- and CI mode (HRGC-EI/CIMS). In cherimoya (A. cherimolia, Mill.) fruit pulp 47 acids were characterized; major compounds were hexanoic (3 mg/kg) and octanoic (1 mg/kg) acid. Fifty one acids were identified in guava (P. guajava, L.), 54 in mango (M, indica, L., var. Alphonso) and 56 in papaya (C. papaya, L.). (E)-cinnamoic acid (0.4 mg/kg) and (Z)-3-hexenoic acid (0.2 mg/kg) were determined as major constituents in guava; in mango 5-hydroxy-(Z)-7-decenoic acid (2 mg/kg) and 3-hydroxyoctanoic acid (1.1 mg/kg) and in papaya pulp butanoic acid (1.2 mg/kg) were established as major constituents.
Clinical References on Manaca (Brunfelsia uniflorus)
Ruppelt BM, et al. Pharmacological screening of plants recommended by folk medicine as anti-snake venom--I. Analgesic and anti-inflammatory activities. Mem Inst Oswaldo Cruz, 1991
(Abstract Available)
Iyer RP, et al. Brunfelsia hopeana I: Hippocratic screening and antiinflammatory evaluation. Lloydia, 1977 Jul-Aug
(Abstract Available)
Spainhour CB Jr, et al. A toxicological investigation of the garden shrub Brunfelsia calcyina var. Floribunda (yesterday-today-and-tomorrow) in three species. J Vet Diagn Invest, 1990 Jan
Pharmacological screening of plants recommended by folk medicine as anti-snake venom--I. Analgesic and anti-inflammatory activities.
Ruppelt BM; Pereira EF; Gonçalves LC; Pereira NA
Departamento de Farmacologia, CCS-ICB, UFRJ, Ilha do Fundão, Rio de Janeiro, Brasil.
Mem Inst Oswaldo Cruz, 86 Suppl 2:1991, 203-5
Abstract
We have observed that several plants used popularly as anti-snake venom show anti-inflammatory activity. From the list prepared by Rizzini, Mors and Pereira some species have been selected and tested for analgesic activity (number of contortions) and anti-inflammatory activity (Evans blue dye diffusion--1% solution) according to Whittle's technique (intraperitoneal administration of 0.1 N-acetic acid 0.1 ml/10 g) in mice. Previous oral administration of a 10% infusion (dry plant) or 20% (fresh plant) corresponding to 1 or 2 g/kg of Apuleia leiocarpa, Casearia sylvestris, Brunfelsia uniflora, Chiococca brachiata, Cynara scolymus, Dorstenia brasiliensis, Elephantopus scaber, Marsypianthes chamaedrys, Mikania glomerata and Trianosperma tayuya demonstrated analgesic and/or anti-inflammatory activities of varied intensity.
Brunfelsia hopeana I: Hippocratic screening and antiinflammatory evaluation.
Iyer RP; Brown JK; Chaubal MG; Malone MH
Lloydia, 40: 4, 1977 Jul-Aug, 356-60
Abstract
Hippocratic screening, in rats, of the whole root and extracts of Brunfelsia hopeana administered intraperitonially indicated that the whole root has CNS depressent activity and that the chloroform extract (F) which contains the basic or 'alkaloidal' fraction concentrates this activity. Extract (F) at an oral dose level of 100 mg/kg, was equally effective (w/w) as phenylbutazone in reducing carrageenin-induced pedal edema in rats.
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