Clinical References on Pau d'arco (Tabebuia avellanedae, sp.)
Pinto AV, et al. Trypanocidal activity of synthetic heterocyclic derivatives of active quinones from Tabebuia sp. Arzneimittelforschung. 1997 Jan;47(1):74-9.
(Abstract Available)
Anesini C, et al. Screening of plants used in Argentine folk medicine for antimicrobial activity. J Ethnopharmacol, 1993 Jun
(Abstract Available)
Binutu OA, et al. Antimicrobial potentials of some plant species of the Bignoniaceae family. Afr J Med Med Sci, 1994 Sep
(Abstract Available)
Dinnen RD, et al. The search for novel anticancer agents: a differentiation-based assay and analysis of a folklore product. Anticancer Res. 1997 Mar-Apr;17(2A):1027-33.
(Abstract Available)
Ueda S, et al. Production of anti-tumour-promoting furanonaphthoquinones in Tabebuia avellanedae cell cultures. Phytochemistry, 1994 May
Grazziotin JD, et al. Phytochemical and analgesic investigation of Tabebuia chrysotricha. J Ethnopharmacol, 1992 Jun
Vidal-Tessier AM, et al. [Lipophilic quinones of the trunk wood of Tabebuia serratifolia
(Vahl.) Nichols] Ann Pharm Fr, 1988
Rao MM, et al. Plant anticancer agents. XII. Isolation and structure elucidation of new
cytotoxic quinones from Tabebuia cassinoides. J Nat Prod, 1982 Sep-Oct
Joshi KC, et al. Chemical examination of the roots of TabePlanta Med, 1977 May
Santana CF de, et al. [Antitumoral and toxicological properties of extracts of bark and various wood components of Pau d'arco (Tabebuia avellanedae)] Rev Inst Antibiot (Recife), 1968 Dec
Anonymous. Questionable methods of cancer management: 'nutritional' therapies. CA Cancer J Clin, 1993 Sep-Oct
Santana CF de, et al. [Antitumoral and toxicological properties of extracts of bark and various wood components of Pau d'arco (Tabebuia avellanedae)] Rev Inst Antibiot (Recife), 1968 Dec
Ueda S, et al. Production of anti-tumour-promoting furanonaphthoquinones in Tabebuia avellanedae cell cultures. Phytochemistry, 1994 May
Santana CF de, et al. [Antitumoral and toxicological properties of extracts of bark and various wood components of Pau d'arco (Tabebuia avellanedae)] Rev Inst Antibiot (Recife), 1968 Dec
Sreening of plants used in Argentine folk medicine for antimicrobial activity.
Anesini C; Perez C
Catedra de Farmacologia, Facultad de Odontologia, Universidad de Buenos Aires, Argentina.
J Ethnopharmacol, 39: 2, 1993 Jun, 119-28
Abstract
Screening of 132 extracts from Argentine folk-medicinal plants for antimicrobial activity has been conducted using a penicillin G resistant strain of Staphylococcus aureus, Escherichia coli and Aspergillus niger as test microorganisms. Cephazolin, ampicillin and miconazole were used as standard antibiotics and concentration-response curves were obtained using the agar-well diffusion method. Boiling water extracts of plant materials were tested and 12 species were active against Staphylococcus aureus, whereas 10 were effective against Escherichia coli and 4 against Aspergillus niger. Tabebuia impetiginosa bark, Achyrocline sp. aerials parts, Larrea divaricata leaves, Rosa borboniana flowers, Punica granatum fruit pericarp, Psidium guineense fruit pericarp, Lithrea ternifolia leaves and Allium sativum bulbs produced some of the more active extracts.
Antimicrobial potentials of some plant species of the Bignoniaceae family.
Binutu OA; Lajubutu BA
Department of Pharmacognosy, College of Medicine, University of Ibadan, Nigeria.
Afr J Med Med Sci, 23: 3, 1994 Sep, 269-73
Abstract
The methanol extracts of the leaves and stem bark of four Bignoniaceae plants Jacaranda mimosifolia D. Dol., Tecoma stans Linn., Tabebuia rosea (Bertol) D.C., and Crescentia cujete Linn. were studied for their antimicrobial activity using a wide range of Gram-positive and Gram-negative bacteria and fungi. Extracts of both the leaves and stem bark of majority of plant species studied showed variable but remarkable broad spectrum antimicrobial activity. However, methanol extracts of Tecoma stans leaves was found to be effective against only Candida albicans at the concentrations employed. It was observed that the extracts of stem bark generally showed better antimicrobial activity than those of the leaves and some organisms were selectively more sensitive to the extracts than others. Preliminary phytochemical screening of these plants revealed the presence of tannins, flavonoids, alkaloids, quinones and traces of saponins. The antimicrobial activity observed are discussed in relation to the chemical constituents reportedly isolated from these plants and their traditional uses.
Trypanocidal activity of synthetic heterocyclic derivatives
of active quinones from Tabebuia sp.
Pinto AV, Pinto CN, Pinto M do C, Rita RS, Pezzella CA, de Castro SL
Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro, Brazil.
Arzneimittelforschung 1997 Jan;47(1):74-9
Continuing a program on the chemistry and biological activity of compounds from the Brazilian flora,
the lytic activity against bloodstream forms of T. cruzi of nine new heterocyclic naphthooxazole and
naphthoimidazole derivatives obtained from the reaction of naphtoquinones isolated from Tabebuia
sp. (Tecoma) with amino-containing reagents has been studied. Also for the first time the biological
activity of allyl derivatives of lawsone, a natural quinone from Lausonia alba inactive against T. cruzi,
is reported. The introduction of an allyl group in lawsone gives rise to O-allyl-lawsone and
C-allyl-lawsone that showed activity against the parasite, with ID50 values of 420.7 +/- 71.1 and
330.7 +/- 62.4 mumol/l, respectively. The trypanocidal activity of the naphtho heterocyclics
synthesized from the original quinones showed no concordant behavior in relation to the parent
compound. Six of nine of the synthesized compounds presented lower ID50 values than crystal
violet, indicating a general trend of activity among naphthalenic heterocyclics of the oxazole/imidazole
type. However, their chemical structures do not endow them with the capacity of free radical
generation by biological reduction as the quinoidal moiety, nor do they have chemical reducible
appendage like the nitro group of nifurtimox and benznidazole, responsible for such behaviour. As a
hypothesis, the pattern of their biological actions should be focused in other aspects of their chemical
structures. Because of their polycyclic planar topology, these derivatives are potential candidates for
experimental tests as DNA intercalating agents.
The search for novel anticancer agents: a
differentiation-based assay and analysis of a folklore
product.
Dinnen RD, Ebisuzaki K
Department of Microbiology and Immunology, University of Western Ontario, London, Canada.
Anticancer Res 1997 Mar-Apr;17(2A):1027-33
One alternative approach to the current use of cytotoxic anticancer drugs involves the use of
differentiation-inducing agents. However, a wider application of this strategy would require the
development of assays to search for new differentiation-inducing agents. In this report we describe an
in vitro assay using the murine erythroleukemia (clone 3-1) cells. Tests for the efficacy of this assay
for the analysis of antineoplastic activity in natural products led to studies on pau d'arco, a South
American folklore product used in the treatment of cancer. Purification of the activity in aqueous
extracts by solvent partition and thin layer chromatography (TLC) indicated the presence of two
activities, one of which was identified as lapachol. The activity in the pau d'arco extracts and of
lapachol was inhibited by vitamin K1. As a vitamin K antagonist, lapachol might target such vitamin
K-dependent reactions as the activation of a ligand for the Axl receptor tyrosine kinase.
Clinical References on Pata de Vaca (Bauhinia forficata)
Clinical trial of Myrcia uniflora and Bauhinia forficata leaf extracts in normal and diabetic patients.
Russo EM; Reichelt AA; De-Sá JR; Furlanetto RP; Moisés RC; Kasamatsu TS; Chacra AR
Disciplina de Endocrinologia, Escola Paulista de Medicina, São Paulo, Brasil.
Braz J Med Biol Res, 23: 1, 1990, 11-20
Abstract
1. Myrcia uniflora and Bauhinia forficata were compared with placebo for their hypoglycemic effect in randomized cross-over double-blind studies in 2 groups of normal subjects (10 subjects each) and 2 groups of Type II diabetic patients (18 in the M. uniflora group and 16 in the B. forficata group). The protocol with each plant lasted 56 days. 2. After the ingestion of infusions of 3 g leaves/day of M. uniflora and B. forficata leaves, no acute or chronic effects on plasma glucose levels or glycated hemoglobin were found in either group. However, plasma insulin levels in the diabetic group were lower after M. uniflora than after placebo. 3. Among other clinical parameters tested, a statistically significant difference was found only in the alkaline phosphatase level after placebo compared with that after M. uniflora in the normal group. 4. There were no differences in any clinical parameters after the use of placebo or of B. forficata. 5. We conclude that infusions prepared from the leaves of M. uniflora or B. forficata have no hypoglycemic effect on normal subjects or Type II diabetic patients.
Clinical References on Pedra Hume Caa (Myrcia uniflora, salicfolia)
Pepato MT, et al. Assessment of the antidiabetic activity of Myrcia uniflora extracts in streptozotocin diabetic rats. Diabetes Res, 1993
(Abstract Available)
Russo EM, et al. Clinical trial of Myrcia uniflora and Bauhinia forficata leaf extracts in normal and diabetic patients. (Braz J Med Biol Res, 1990
(Abstract Available)
Clinical trial of Myrcia uniflora and Bauhinia forficata leaf extracts in normal and diabetic patients.
Russo EM; Reichelt AA; De-Sá JR; Furlanetto RP; Moisés RC; Kasamatsu TS; Chacra AR
Disciplina de Endocrinologia, Escola Paulista de Medicina, São Paulo, Brasil.
Braz J Med Biol Res, 23: 1, 1990, 11-20
Abstract
1. Myrcia uniflora and Bauhinia forficata were compared with placebo for their hypoglycemic effect in randomized cross-over double-blind studies in 2 groups of normal subjects (10 subjects each) and 2 groups of Type II diabetic patients (18 in the M. uniflora group and 16 in the B. forficata group). The protocol with each plant lasted 56 days. 2. After the ingestion of infusions of 3 g leaves/day of M. uniflora and B. forficata leaves, no acute or chronic effects on plasma glucose levels or glycated hemoglobin were found in either group. However, plasma insulin levels in the diabetic group were lower after M. uniflora than after placebo. 3. Among other clinical parameters tested, a statistically significant difference was found only in the alkaline phosphatase level after placebo compared with that after M. uniflora in the normal group. 4. There were no differences in any clinical parameters after the use of placebo or of B. forficata. 5. We conclude that infusions prepared from the leaves of M. uniflora or B. forficata have no hypoglycemic effect on normal subjects or Type II diabetic patients.
Assessment of the antidiabetic activity of Myrcia uniflora extracts in streptozotocin diabetic rats.
Pepato MT; Oliveira JR; Kettelhut IC; Migliorini RH
Department of Biochemistry, School of Medicine, University of São Paulo, Ribeirão Preto, Brazil.
Diabetes Res, 22: 2, 1993, 49-57
Abstract
Several metabolic parameters were used to determine the evolution of the diabetic state of streptozotocin diabetic rats treated with aqueous leaf extracts from Myricia uniflora, a plant widely used in northern Brazil for treatment of diabetes. The effect of the extracts on the intestinal absorption of glucose and on the evolution of diabetes of diabetic rats adapted to a high protein, carbohydrate-free diet were also investigated. Treated rats received twice a day, by gavage, during three weeks, 7.5 mg of lyophilized powder, corresponding to about 60 mg of dried leaves, prepared from percolations with boiled water, Treatment of diabetic rats fed a stock, balanced diet did not affect body weight gain but reduced the hyperglycemia, polyphagia, polydipsia, urine volume and the urinary excretion of glucose and urea. Myrcia administration for 3 weeks had no effect on the weight of epididymal and retroperitoneal adipose tissue, or on the concentrations of pancreatic and serum insulin. The intestinal absorption of glucose, measured with a perfusion technique in situ, was markedly inhibited by Myrcia (7.5 mg of lyophilized powder per ml of perfusion solution). The effects of Myrcia treatment on diabetic rats adapted to a carbohydrate-free diet were similar to those obtained in rats fed the stock diet. The data show that aqueous extracts of Myrcia has a beneficial effect on the diabetic state, mainly by improving metabolic parameters of glucose homeostasis.(ABSTRACT TRUNCATED AT 250 WORDS)
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